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KMID : 1123920110250040641
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 4 p.641 ~ p.649
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Effects of Root of Liriope Spicata on LPS-induced Lung Injury
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Lee Eung-Seok
Yang Soo-Young
Kim Min-Hee
Namgung Uk
Park Yang-Chun
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Abstract
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This study was purposed to evaluate the effects of root of Liriope spicata (RLS) on LPS-induced COPD (chronic obstructive pulmonary disease) model. The extract of RLS was treated to A549 cells and LPS-induced COPD mice model. Then, various parameters such as cell-based cyto-protective activity and histopathological finding were analyzed. RLS showed a protective effect on LPS-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, protein level of cyclin B1, Cdc2, and phospho-Erk1/2, and gene expression of TNF- and IL- in A549 cells. RLS treatment also revealed the protective effect on LPS-induced lung injury in COPD mice model. This effect was evidenced via histopathological finding including immunofluence stains against caspase 3, and protein level of cyclin B1, Cdc2, and Erk1/2 in lung tissue. These data suggest that RLS has a pharmaceutical properties on lung injury. This study would provide an scientific evidence for the efficacy of RLS for clinical application to patients with COPD.
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KEYWORD
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root of Liriope spicata, chronic obstructive pulmonary disease, emphysema, A549 cell
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